With a place in the Sky Bet Championship on the line, Oxford United and Wycombe Wanderers go head-to-head at Wembley Stadium.
Manchester United welcome Southampton to Old Trafford as a big weekend of Premier League action concludes with Monday Night Football.
Promotion-chasing West Bromwich Albion welcome Fulham to The Hawthorns in the Sky Bet Championship.
Frank Lampard's Chelsea - in a battle for the top four - play host to Norwich City at Stamford Bridge in the Premier League.
Promotion-chasing Brentford take on Preston North End at Griffin Park in midweek action from the Sky Bet Championship.
Manchester City host Eddie Howe's Bournemouth at the Etihad Stadium, with the visitors fighting for points as they look to escape relegation.
Mikel Arteta's Arsenal take on Premier League champions Liverpool at the Emirates Stadium in a big midweek clash from the top flight.